Rosenbrock, Holger: search on Z-Library

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1

The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents

Rosenbrock, Holger, Giovannini, Riccardo, SchÃ¤nzle, Gerhard, Koros, Eliza, Runge, Frank, Fuchs, Holger, Marti, Anelise, Reymann, Klaus G., SchrÃ¶der, Ulrich H., Fedele, Ernesto, Dorner-Ciossek, Corne

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2019

File:

PDF, 970 KB

2019

2

Suppression of Parvalbumin Interneuron Activity in the Prefrontal Cortex Recapitulates Features of Impaired Excitatory/Inhibitory Balance and Sensory Processing in Schizophrenia

Toader, Oana, von Heimendahl, Moritz, Schuelert, Niklas, Nissen, Wiebke, Rosenbrock, Holger

Journal:

Schizophrenia Bulletin

Year:

2020

File:

PDF, 1.39 MB

2020

3

Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP

Katja S. Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbrock

Journal:

Neuropharmacology

Year:

2012

Language:

english

File:

PDF, 845 KB

english, 2012

4

Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell–Derived Neurons

Traub, Stefanie, Stahl, Heiko, Rosenbrock, Holger, Simon, Eric, Florin, Lore, Hospach, Lisa, Hörer, Stefan, Heilker, Ralf

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 933 KB

english, 2017

5

868. Early Intervention in Attenuated Psychosis Syndrome: A Phase II Study Evaluating Efficacy, Safety, and Tolerability of Oral BI 409306

Keefe, Richard, Woods, Scott, Cannon, Tyrone, Ruhrmann, Stephan, Mathalon, Daniel, McGuire, Philip, Fillon, Gwenaëlle, Rosenbrock, Holger, Sand, Michael

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

6

PDE9 INHIBITION IMPROVES COGNITION IN MICE BY A MECHANISM DIFFERENT FROM THE ACETYLCHOLINE ESTERASE INHIBITOR DONEPEZIL

Rosenbrock, Holger, Giovannini, Riccardo, Fuchs, Klaus, Dorner-Ciossek, Cornelia

Journal:

Alzheimer's & Dementia

Year:

2017

Language:

english

File:

PDF, 217 KB

english, 2017

7

Poster #M15 PRE-SYNAPTIC LOCALIZATION OF PDE2 ENZYME AND PHARMACOLOGICAL CHARACTERIZATION OF THE PDE2 INHIBITOR PF-999 IN MODELS RELATED TO COGNITIVE SYMPTOMS OF SCHIZOPHRENIA

Rosenbrock, Holger, Kroker, Katja S., Bertani, Barbara, Stierstorfer, Birgit, Dorner-Ciossek, Cornelia, Arban, Roberto

Journal:

Schizophrenia Research

Year:

2014

Language:

english

File:

PDF, 87 KB

english, 2014

8

S141. TRANSGENIC OVEREXPRESSION OF THE TYPE III ISOFORM OF NEUREGULIN 1 IN MICE INDUCES ABNORMALITIES ON AUDITORY EVENT RELATED EEG BIOMARKERS RELATED TO SCHIZOPHRENIA

Rosenbrock, Holger, Nissen, Wiebke, Arban, Roberto, Moritz, Rossner, Markus, Schwab, Dorner-Ciossek, Cornelia, Schülert, Niklas

Journal:

Schizophrenia Bulletin

Year:

2018

Language:

english

File:

PDF, 80 KB

english, 2018

9

T178. MICROPIPETTE-GUIDED DRUG ADMINISTRATION (MDA) METHOD AS A NOVEL PHARMACOLOGICAL TREATMENT METHOD IN MICE: PRECLINICAL VALIDATION USING RISPERIDONE IN THE MATERNAL IMMUNE ACTIVATION MODEL OF NEURODEVELOPMENTAL DISORDERS

Scarborough, Joseph, MÃ¼ller, Flavia, Dorner-Ciossek, Cornelia, Arban, Roberto, Rosenbrock, Holger, Meyer, Urs, Richetto, Juliet

Journal:

Schizophrenia Bulletin

Year:

2020

File:

PDF, 81 KB

2020

10

Noticeboard

Rosenbrock, Holger, Kroker, Katja S., Bertani, Barbara, Stierstorfer, Birgit, Dorner-Ciossek, Cornelia, Arban, Roberto

Journal:

International Journal of Pharmaceutics

Year:

1988

Language:

english

File:

PDF, 56 KB

english, 1988

11

A comprehensive analysis of auditory event-related potentials and network oscillations in an NMDA receptor antagonist mouse model using a novel wireless recording technology

Schuelert, Niklas, Dorner-Ciossek, Cornelia, Brendel, Michael, Rosenbrock, Holger

Journal:

Physiological Reports

Year:

2018

Language:

english

File:

PDF, 1.30 MB

english, 2018

12

Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain

Holger Rosenbrock, Christoph E. Hagemeyer, Margarethe Ditter, Rolf Knoth, Benedict Volk

Journal:

Neurotoxicity Research

Year:

2001

Language:

english

File:

PDF, 1.86 MB

english, 2001

13

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

Holger Rosenbrock, Gert Kramer, Scott Hobson, Eliza Koros, Marc Grundl, Matthias Grauert, Klaus G. Reymann, Ulrich H. Schröder

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

14

RESTORING LONG-TERM POTENTIATION IMPAIRED BY AMYLOID-BETA OLIGOMERS: COMPARISON OF A BROADLY-SPECIFIC ANTI AMYLOID-BETA NANOBODY AND A MONOMER-SPECIFIC ANTIBODY

Kroker, Katja, Hobson, Scott, Rosenbrock, Holger, Lamla, Thorsten, Vercammen, Jo, Beste, Gerald, Merchiers, Pascal, Dorner-Ciossek, Cornelia, Lenter, Martin

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 54 KB

english, 2014

15

BEHAVIORAL CHARACTERIZATION OF TG2576 MICE IN TOUCHSCREEN TASKS TARGETING DIFFERENT ASPECTS OF LEARNING AND MEMORY

Dorner-Ciossek, Cornelia, Delotterie, David, Mathis, Chantal, Cassel, Jean-Christophe, Rosenbrock, Holger, Marti, Anelise

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 76 KB

english, 2014

16

Touchscreen tasks in mice to demonstrate differences between hippocampal and striatal functions

Delotterie, David F., Mathis, Chantal, Cassel, Jean-Christophe, Rosenbrock, Holger, Dorner-Ciossek, Cornelia, Marti, Anelise

Journal:

Neurobiology of Learning and Memory

Year:

2015

Language:

english

File:

PDF, 1.71 MB

english, 2015

17

Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons

Ilyas Singec, Rolf Knoth, Margarethe Ditter, Christoph E. Hagemeyer, Holger Rosenbrock, Michael Frotscher, Benedikt Volk

Journal:

The Journal of Comparative Neurology

Year:

2002

Language:

english

File:

PDF, 3.96 MB

english, 2002

18

Automated classification of the behavior of rats in the forced swimming test with support vector machines

Holger Fröhlich, Andreas Hoenselaar, Jonas Eichner, Holger Rosenbrock, Gerald Birk, Andreas Zell

Journal:

Neural Networks

Year:

2008

Language:

english

File:

PDF, 1.00 MB

english, 2008

19

Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP

Katja S. Kroker, Georg Rast, Holger Rosenbrock

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 600 KB

english, 2011

20

IMPROVING COGNITIVE FUNCTION IN RODENTS VIA INCREASING GLYCINE LEVELS IN BRAIN BY THE NOVEL GLYCINE TRANSPORTER-1 INHIBITOR BI 425809

Rosenbrock, Holger, Giovannini, Riccardo, Schmid, Bernhard, Kramer, Gert, Arban, Roberto, Dorner-Ciossek, Cornelia, Wunderlich, Glen

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 78 KB

english, 2016

21

M15. Early Intervention in Attenuated Psychosis Syndrome: A Phase II Study Evaluating Efficacy, Safety, and Tolerability of Oral BI 409306

Keefe, Richard, Woods, Scott, Cannon, Tyrone, Ruhrmann, Stephan, Mathalon, Daniel, McGuire, Philip, Fillon, Gwenaëlle, Rosenbrock, Holger, Sand, Michael

Journal:

Schizophrenia Bulletin

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

22

S31. ENHANCEMENT OF SYNAPTIC PLASTICITY BY COMBINATION OF PDE2 AND PDE9 INHIBITION PRESUMABLY VIA PRE- AND POST-SYNAPTIC MECHANISMS

Rosenbrock, Holger, Kroker, Katja, Stierstorfer, Birgit, Hobson, Scott, Arban, Roberto, Dorner-Ciossek, Cornelia

Journal:

Schizophrenia Bulletin

Year:

2020

File:

PDF, 76 KB

2020

23

Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP

Katja S. Kroker, Georg Rast, Holger Rosenbrock

Journal:

Neuropharmacology

Year:

2011

Language:

english

File:

PDF, 717 KB

english, 2011

24

Effects of specific nicotinic acetylcholine receptor agonists on hippocampal long-term potentiation

Holger Rosenbrock, Cornelia Dorner-Ciossek, Katja Kroker, Georg Rast

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 47 KB

english, 2011

25

Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders

Scarborough, Joseph, Mueller, Flavia, Arban, Roberto, Dorner-Ciossek, Cornelia, Weber-Stadlbauer, Ulrike, Rosenbrock, Holger, Meyer, Urs, Richetto, Juliet

Journal:

Brain, Behavior, and Immunity

Year:

2020

File:

PDF, 2.58 MB

2020

26

Globular and Protofibrillar Aβ Aggregates Impair Neurotransmission by Different Mechanisms

Moreth, Jens, Kroker, Katja S., Schwanzar, Daniel, Schnack, Cathrin, von Arnim, Christine A. F., Hengerer, Bastian, Rosenbrock, Holger, Kussmaul, Lothar

Journal:

Year:

2013

Language:

english

File:

PDF, 3.70 MB

english, 2013

27

Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study

Moschetti, Viktoria, Desch, Michael, Goetz, Sophia, Liesenfeld, Karl-Heinz, Rosenbrock, Holger, Kammerer, Klaus-Peter, Wunderlich, Glen, Wind, Sven

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Year:

2017

Language:

english

File:

PDF, 616 KB

english, 2017

28

Upscaling of hiPS Cell–Derived Neurons for High-Throughput Screening

Traub, Stefanie, Stahl, Heiko, Rosenbrock, Holger, Simon, Eric, Heilker, Ralf

Journal:

Journal of Biomolecular Screening

Year:

2016

Language:

english

File:

PDF, 4.53 MB

english, 2016

29

F21. THE PHOSPHODIESTERASE-9 INHIBITOR BI 409306 ATTENUATES SOCIAL INTERACTION AND DOPAMINERGIC DEFICITS IN ADULT OFFSPRING OF POLY(I:C)-BASED MATERNAL IMMUNE ACTIVATION NEURODEVELOPMENTAL MOUSE MODEL

Richetto, Juliet, Scarborough, Joseph, Arban, Roberto, Dorner-Ciossek, Cornelia, Rosenbrock, Holger, Meyer, Urs

Journal:

Schizophrenia Bulletin

Year:

2019

Language:

english

File:

PDF, 75 KB

english, 2019

30

A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments

Katja Sabine Kroker, Holger Rosenbrock, Georg Rast

Journal:

Journal of Neuroscience Methods

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

31

Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test

Holger Rosenbrock, Anita Bloching, Carmen Weiss, Franco Borsini

Journal:

Pharmacology Biochemistry and Behavior

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

32

P2-459: Long-lasting improvement in long-term object memory after subchronic rolipram treatment

Rosenbrock, Holger, Rutten, Kris, Prickaerts, Jos, Schaenzle, Gerhard, Dorner-Ciossek, Cornelia, Blokland, Arjan

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 128 KB

english, 2008

33

List of contents for Deep-Sea Research

Rosenbrock, Holger, Rutten, Kris, Prickaerts, Jos, Schaenzle, Gerhard, Dorner-Ciossek, Cornelia, Blokland, Arjan

Journal:

Continental Shelf Research

Year:

1990

Language:

english

File:

PDF, 124 KB

english, 1990

34

Improving synaptic plasticity and cognitive function in rodents by the novel phosphodiesterase 9A inhibitor bi 409306

Rosenbrock, Holger, Marti, Anelise, Koros, Eliza, Runge, Frank, Fuchs, Holger, Giovannini, Riccardo, Dorner-Ciossek, Cornelia

Journal:

Alzheimer's & Dementia

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

35

F196. Transgenic Overexpression of the Type III Isoform of Neuregulin 1 in Mice Induces Abnormalities on Auditory Event Related EEG Biomarkers Related to Schizophrenia Accompanied by Reduction of Parvalbumin Positive Interneurons in the Prefrontal Cortex

Schuelert, Niklas, Nissen, Wiebke, Mack, Volker, Jaeger, Stefan, Arban, Roberto, Schwab, Markus, Rossner, Moritz, Dorner-Ciossek, Cornelia, Rosenbrock, Holger

Journal:

Biological Psychiatry

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

36

PDE9A inhibition rescues amyloid beta-induced deficits in synaptic plasticity and cognition

Kroker, Katja S., Mathis, Chantal, Marti, Anelise, Cassel, Jean-Christophe, Rosenbrock, Holger, Dorner-Ciossek, Cornelia

Journal:

Neurobiology of Aging

Year:

2014

Language:

english

File:

PDF, 735 KB

english, 2014

37

Targeting the Dopamine 1 Receptor or its Downstream Signalling by Inhibiting Phosphodiesterase-1 Improves Cognitive Performance

Pekcec, Anton, Schülert, Niklas, Stierstorfer, Birgit, Deiana, Serena, Dorner-Ciossek, Cornelia, Rosenbrock, Holger

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 961 KB

english, 2018

38

Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation

Fernández-Fernández, Diego, Dorner-Ciossek, Cornelia, Kroker, Katja S., Rosenbrock, Holger

Journal:

Journal of Neuroscience Research

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

39

Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies

Rosenbrock, Holger, Desch, Michael, Kleiner, Oliver, Dorner-Ciossek, Cornelia, Schmid, Bernhard, Keller, Sascha, Schlecker, Christina, Moschetti, Viktoria, Goetz, Sophia, Liesenfeld, Karl-Heinz, Fillo

Journal:

Clinical and Translational Science

Year:

2018

Language:

english

File:

PDF, 332 KB

english, 2018

40

F161. Effects of Metabotropic Glutamate 2/3 Receptor Activation on Deficits of Neural Network Function Induced by Optogenetic Inhibition of Parvalbumin-Positive Interneurons in the Mouse Prefrontal Cortex

Toader, Oana, Nissen, Wiebke, Schuelert, Niklas, von Heimendahl, Moritz, Rosenbrock, Holger

Journal:

Biological Psychiatry

Year:

2019

Language:

english

File:

PDF, 45 KB

english, 2019

41

Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats

Holger Rosenbrock, Eliza Koros, Anita Bloching, Jana Podhorna, Franco Borsini

Journal:

Year:

2005

Language:

english

File:

PDF, 754 KB

english, 2005

42

The Selective mGlu5 Receptor Antagonist MTEP, Similar to NMDA Receptor Antagonists, Induces Social Isolation in Rats

Koros, Eliza, Rosenbrock, Holger, Birk, Gerald, Weiss, Carmen, Sams-Dodd, Frank

Journal:

Neuropsychopharmacology

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

43

Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus

Fernández-Fernández, Diego, Rosenbrock, Holger, Kroker, Katja S.

Journal:

Year:

2015

Language:

english

File:

PDF, 736 KB

english, 2015

44

Restoring long-term potentiation impaired by amyloid-beta oligomers: Comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists

Kroker, Katja S., Moreth, Jens, Kussmaul, Lothar, Rast, Georg, Rosenbrock, Holger

Journal:

Brain Research Bulletin

Year:

2013

Language:

english

File:

PDF, 1.39 MB

english, 2013

45

669. GPR52 Agonists Represent a Novel Approach to Treat Cognitive Deficits Associated with Schizophrenia

Grottick, Andy, Schuelert, Niklas, Rosenbrock, Holger, von Heimendahl, Moritz, Arban, Roberto, Hobson, Scott

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 44 KB

english, 2017

46

The safety, tolerability and pharmacokinetics of BI 409306, a novel and potent PDE9 inhibitor: Overview of three Phase I randomised trials in healthy volunteers

Moschetti, Viktoria, Kim, Maria, Sand, Michael, Wunderlich, Glen, Andersen, Grit, Feifel, Ulrich, Jang, In-Jin, Timmer, Wolfgang, Rosenbrock, Holger, Boland, Katja

Journal:

European Neuropsychopharmacology

Year:

2018

Language:

english

File:

PDF, 473 KB

english, 2018

47

Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine

Marianne H. Larsen, Holger Rosenbrock, Frank Sams-Dodd, Jens D. Mikkelsen

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 501 KB

english, 2007

48

SA11. Analysis of Auditory Event-Related Potentials and Oscillation in a Mouse Model Related to Schizophrenia by a Novel Technology for Wireless Recording

Rosenbrock, Holger, Dorner-Ciossek, Cornelia

Journal:

Schizophrenia Bulletin

Year:

2017

Language:

english

File:

PDF, 54 KB

english, 2017

49

S188. The Phosphodiesterase-9 Inhibitor BI 409306 Attenuates Social Interaction and Dopaminergic Deficits in Adult Offspring of poly(I:C)-Based Maternal Immune Activation Neurodevelopmental Mouse Model

Arban, Roberto, Richetto, Juliet, Scarborough, Joseph, Dorner-Ciossek, Cornelia, Rosenbrock, Holger, Meyer, Urs

Journal:

Biological Psychiatry

Year:

2019

Language:

english

File:

PDF, 66 KB

english, 2019

50

Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement

Holger Rosenbrock

Journal:

BMC Pharmacology and Toxicology

Year:

2015

Language:

english

File:

PDF, 202 KB

english, 2015

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